{"id":93,"date":"2020-04-29T14:05:22","date_gmt":"2020-04-29T14:05:22","guid":{"rendered":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/?post_type=chapter&#038;p=93"},"modified":"2021-09-05T16:24:45","modified_gmt":"2021-09-05T16:24:45","slug":"cells-of-the-nervous-system","status":"publish","type":"chapter","link":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/chapter\/cells-of-the-nervous-system\/","title":{"raw":"Cells of the Nervous System","rendered":"Cells of the Nervous System"},"content":{"raw":"<div class=\"PageContent-ny9bj0-0 iapMdy\">\r\n<div id=\"main-content\" class=\"MainContent__HideOutline-sc-6yy1if-0 bdVAq\">\r\n<div id=\"cec4ceec-8232-473d-b4b7-405524a93eac\">\r\n<div id=\"41033\" class=\"ui-has-child-title\"><header>\r\n<div class=\"textbox textbox--learning-objectives\"><header class=\"textbox__header\">\r\n<p class=\"textbox__title\"><span style=\"color: #ffffff\">Learning Objectives<\/span><\/p>\r\n\r\n<\/header>\r\n<div class=\"textbox__content\"><section>By the end of this section, you will be able to:\r\n<ul>\r\n \t<li>Identify the basic parts of a neuron<\/li>\r\n \t<li>Describe how neurons communicate with each other<\/li>\r\n \t<li>Explain how drugs act as agonists or antagonists for a given neurotransmitter system<\/li>\r\n<\/ul>\r\n<\/section><\/div>\r\n<\/div>\r\n<\/header><\/div>\r\n<p id=\"fs-id1365204\" class=\"indent no-indent\">Psychologists striving to understand the human mind may study the nervous system. Learning how the body's cells and organs function can help us understand the biological basis of human psychology. The\u00a0<strong><span id=\"term132\">nervous system<\/span><\/strong>\u00a0is composed of two basic cell types: glial cells (also known as glia) and neurons. <strong>Glial cells<\/strong> are traditionally thought to play a supportive role to neurons, both physically and metabolically.\u00a0<span id=\"term133\">Glial cells<\/span>\u00a0provide scaffolding on which the nervous system is built, help neurons line up closely with each other to allow neuronal communication, provide insulation to neurons, transport nutrients and waste products, and mediate immune responses. For years, researchers believed that there were many more glial cells than neurons; however, more recent work from Suzanna Herculano-Houzel's laboratory has called this long-standing assumption into question and has provided important evidence that there may be a nearly 1:1 ratio of glia cells to neurons. This is important because it suggests that human brains are more similar to other primate brains than previously thought (Azevedo et al, 2009; Hercaulano-Houzel, 2012; Herculano-Houzel, 2009).\u00a0<strong><span id=\"term134\">Neurons<\/span><\/strong>, on the other hand, serve as interconnected information processors that are essential for all of the tasks of the nervous system. This section briefly describes the structure and function of neurons.<\/p>\r\n\r\n<section id=\"fs-id1470001\">\r\n<h3>Neuron Structure<\/h3>\r\n<p id=\"fs-id1577075\" class=\"indent no-indent\"><span id=\"term135\" class=\"no-emphasis\">Neurons<\/span>\u00a0are the central building blocks of the nervous system, 100 billion strong at birth. Like all cells, neurons consist of several different parts, each serving a specialized function (<a class=\"autogenerated-content\" href=\"http:\/\/www.mollywellsart.ca\/scientific-illustration.html\">Figure BB.2<\/a>). A neuron\u2019s outer surface is made up of a<strong>\u00a0<span id=\"term136\">semipermeable membrane<\/span><\/strong>. This membrane allows smaller molecules and molecules without an electrical charge to pass through it, while stopping larger or highly charged molecules.<\/p>\r\n\r\n<div id=\"CNX_Psych_03_02_Neuron\" class=\"os-figure\">\r\n<figure>\r\n\r\n[caption id=\"attachment_1406\" align=\"aligncenter\" width=\"1024\"]<img class=\"wp-image-1406 size-large\" src=\"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-1024x741.jpg\" alt=\"An illustration shows a neuron with labeled parts for the cell membrane, dendrite, cell body, axon, and terminal buttons. A myelin sheath covers part of the neuron.\" width=\"1024\" height=\"741\" \/> Figure BB.2 This illustration shows a prototypical neuron, which is being myelinated by a glial cell. (credit: <a href=\"http:\/\/www.mollywellsart.ca\/scientific-illustration.html\">Molly Wells Art<\/a>)[\/caption]<\/figure>\r\n\r\n<p id=\"fs-id1456894\" class=\"indent no-indent\">The nucleus of the neuron is located in the\u00a0<strong><span id=\"term137\">soma<\/span>,<\/strong> or cell body. The soma has branching extensions known as\u00a0<strong><span id=\"term138\">dendrites<\/span><\/strong>. The neuron is a small information processor, and dendrites serve as input sites where signals are received from other neurons. These signals are transmitted electrically across the soma and down a major extension from the soma known as the\u00a0<strong><span id=\"term139\">axon<\/span><\/strong>, which ends at multiple<strong>\u00a0<span id=\"term140\">terminal buttons<\/span><\/strong>. The terminal buttons contain\u00a0<strong><span id=\"term141\">synaptic vesicles<\/span><\/strong>\u00a0that house\u00a0<strong><span id=\"term142\">neurotransmitters<\/span><\/strong>, the chemical messengers of the nervous system.<\/p>\r\n<p id=\"fs-id1565745\">Axons range in length from a fraction of an inch to several feet. In some axons, glial cells form a fatty substance known as the\u00a0<strong><span id=\"term143\">myelin sheath<\/span><\/strong>, which coats the axon and acts as an insulator, increasing the speed at which the signal travels. The myelin sheath is not continuous and there are small gaps that occur down the length of the axon. These gaps in the myelin sheath are known as the\u00a0<strong><span id=\"term144\">Nodes of Ranvier<\/span><\/strong>. The myelin sheath is crucial for the normal operation of the neurons within the nervous system: the loss of the insulation it provides can be detrimental to normal function. To understand how this works, let\u2019s consider an example. Phenylketonuria (fen-ul-key-toe-NU-ree-uh), also called PKU, causes a reduction in myelin and abnormalities in white matter cortical and subcortical structures. The disorder is associated with a variety of issues including severe cognitive deficits, exaggerated reflexes, and seizures (Anderson &amp; Leuzzi, 2010; Huttenlocher, 2000). Another disorder, multiple sclerosis (MS), an autoimmune disorder, involves a large-scale loss of the myelin sheath on axons throughout the nervous system. The resulting interference in the electrical signal prevents the quick transmittal of information by neurons and can lead to a number of symptoms, such as dizziness, fatigue, loss of motor control, and sexual dysfunction. While some treatments may help to modify the course of the disease and manage certain symptoms, there is currently no known cure for multiple sclerosis.<\/p>\r\n<p class=\"no-indent\"><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTneuronalstructure\"><\/a>TRICKY TOPIC: NEURONAL STRUCTURE\r\n<\/strong><\/p>\r\n[embed]https:\/\/youtu.be\/zpWZ5PgZFF0[\/embed]\r\n\r\n<em><span style=\"font-size: 1em\">If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/zpWZ5PgZFF0\">https:\/\/youtu.be\/zpWZ5PgZFF0<\/a><\/span><\/em>\r\n\r\n<\/section><section><em><span id=\"term70\">For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#neuronalstructure\">here<\/a><\/span><\/em><\/section><section><\/section><section>\r\n<p id=\"fs-id1577995\">In healthy individuals, the neuronal signal moves rapidly down the axon to the terminal buttons, where synaptic vesicles release neurotransmitters into the <strong>synaptic cleft<\/strong> (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_Synapse\">Figure BB.3<\/a>). The\u00a0<span id=\"term145\">synaptic cleft<\/span>\u00a0is a very small space between two neurons and is an important site where communication between neurons occurs. Once neurotransmitters are released into the synaptic cleft, they travel across it and bind with corresponding receptors on the dendrite of an adjacent neuron.<strong>\u00a0<span id=\"term146\">Receptors<\/span>,<\/strong> proteins on the cell surface where neurotransmitters attach, vary in shape, with different shapes \u201cmatching\u201d different neurotransmitters.<\/p>\r\n<p id=\"eip-772\">How does a neurotransmitter \u201cknow\u201d which receptor to bind to? The neurotransmitter and the receptor have what is referred to as a lock-and-key relationship\u2014specific neurotransmitters fit specific receptors similar to how a key fits a lock. The neurotransmitter binds to any receptor that it fits.<\/p>\r\n\r\n<div id=\"CNX_Psych_03_02_Synapse\" class=\"os-figure\">\r\n<figure>\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"976\"]<img id=\"54888\" src=\"https:\/\/openstax.org\/resources\/19b96297b4eb951260d2140515a3e7261f82d331\" alt=\"Image (a) shows the synaptic space between two neurons, with neurotransmitters being released into the synapse and attaching to receptors. Image (b) is a micrograph showing a spherical terminal button with part of the exterior removed, revealing a solid interior of small round parts.\" width=\"976\" height=\"428\" \/> Figure BB.3 (a) The synaptic cleft is the space between the terminal button of one neuron and the dendrite of another neuron. (b) In this pseudo-colored image from a scanning electron microscope, a terminal button (green) has been opened to reveal the synaptic vesicles (orange and blue) inside. Each vesicle contains about 10,000 neurotransmitter molecules. (credit b: modification of work by Tina Carvalho, NIH-NIGMS; scale-bar data from Matt Russell)[\/caption]<\/figure>\r\n<\/div>\r\n<\/section><section><section id=\"fs-id1470001\"><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTsyntransmission\"><\/a>TRICKY TOPIC: SYNAPTIC TRANSMISSION\r\n<\/strong>[embed]https:\/\/youtu.be\/M7OMTco-qV4[\/embed]\r\n<p id=\"fs-id1565745\"><em style=\"font-size: 1em\"><span id=\"term70\">If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/M7OMTco-qV4\">https:\/\/youtu.be\/M7OMTco-qV4<\/a><\/span><\/em><\/p>\r\n\r\n<\/section><section id=\"fs-id1470001\"><em><span id=\"term70\">For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#syntransmission\">here<\/a><\/span><\/em><\/section>\r\n<h3>Neuronal Communication<\/h3>\r\n<p id=\"fs-id1560860\">Now that we have learned about the basic structures of the neuron and the role that these structures play in neuronal communication, let\u2019s take a closer look at the signal itself\u2014how it moves through the neuron and then jumps to the next neuron, where the process is repeated.<\/p>\r\n<p id=\"fs-id1500598\">We begin at the neuronal membrane. The\u00a0<span id=\"term147\" class=\"no-emphasis\">neuron<\/span>\u00a0exists in a fluid environment\u2014it is surrounded by extracellular fluid and contains intracellular fluid (i.e., cytoplasm). The neuronal membrane keeps these two fluids separate\u2014a critical role because the electrical signal that passes through the neuron depends on the intra- and extracellular fluids being electrically different. This difference in charge across the membrane, called the\u00a0<strong><span id=\"term148\">membrane potential<\/span><\/strong>, provides energy for the signal.<\/p>\r\n<p id=\"fs-id1561065\">The electrical charge of the fluids is caused by charged molecules (ions) dissolved in the fluid. The semipermeable nature of the neuronal membrane somewhat restricts the movement of these charged molecules, and, as a result, some of the charged particles tend to become more concentrated either inside or outside the cell.<\/p>\r\n<p id=\"fs-id1470173\">Between signals, the neuron membrane\u2019s potential is held in a state of readiness, called the\u00a0<strong><span id=\"term149\">resting potential<\/span>.<\/strong>\u00a0The typical resting potential of a neuron is -70 mV. Like a rubber band stretched out and waiting to spring into action, ions line up on either side of the cell membrane, ready to rush across the membrane when the neuron goes active and the membrane opens its gates (i.e., a\u00a0<span id=\"term150\" class=\"no-emphasis\">sodium-potassium pump<\/span>\u00a0that allows movement of ions across the membrane). Ions in high-concentration areas are ready to move to low-concentration areas, and positive ions are ready to move to areas with a negative charge.<\/p>\r\n<p id=\"fs-id1574264\">In the resting state, sodium (Na<sup>+<\/sup>) is at higher concentrations outside the cell, so it will tend to move into the cell. Potassium (K<sup>+<\/sup>), on the other hand, is more concentrated inside the cell, and will tend to move out of the cell (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_NaKConc\">Figure BB.4<\/a>). In addition, the inside of the cell is slightly negatively charged compared to the outside. This difference in charge, known as the\u00a0<strong>electrochemical gradient,<\/strong>\u00a0provides an additional force on sodium, causing it to move into the cell.<\/p>\r\n\r\n<div id=\"CNX_Psych_03_02_NaKConc\" class=\"os-figure\">\r\n<figure>\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"975\"]<img id=\"68934\" src=\"https:\/\/openstax.org\/resources\/64f9607dcac413179b9f7d0f596305bab38f3800\" alt=\"A close-up illustration depicts the difference in charges across the cell membrane, and shows how Na+ and K+ cells concentrate more closely near the membrane.\" width=\"975\" height=\"368\" \/> Figure BB.4\u00a0At resting potential, Na+\u00a0(blue pentagons) is more highly concentrated outside the cell in the extracellular fluid (shown in blue), whereas K+\u00a0(purple squares) is more highly concentrated near the membrane in the cytoplasm or intracellular fluid. Other molecules, such as chloride ions (yellow circles) and negatively charged proteins (brown squares), help contribute to a positive net charge in the extracellular fluid and a negative net charge in the intracellular fluid.[\/caption]<\/figure>\r\n<p class=\"os-caption-container\"><span style=\"text-align: initial;font-size: 1em\">From this resting potential state, the neuron receives a signal and its state changes abruptly (<\/span><a class=\"autogenerated-content\" style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_ActionP\">Figure BB.5<\/a><span style=\"text-align: initial;font-size: 1em\">). When a neuron receives signals at the dendrites\u2014due to neurotransmitters from an adjacent neuron binding to its receptors\u2014small pores, or gates, open on the neuronal membrane, allowing Na<\/span><sup style=\"text-align: initial\">+<\/sup><span style=\"text-align: initial;font-size: 1em\">\u00a0ions, propelled by both charge and concentration differences, to move into the cell. With this influx of positive ions, the internal charge of the cell becomes more positive. If that charge reaches a certain level, called the\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term151\">threshold of excitation<\/span><\/strong><span style=\"text-align: initial;font-size: 1em\">, the neuron becomes active and the action potential begins.<\/span><\/p>\r\n\r\n<\/div>\r\n<p id=\"eip-267\">Many additional pores open, causing a massive influx of Na<sup>+<\/sup>\u00a0ions and a huge positive spike in the membrane potential, the peak action potential. At the peak of the spike, the sodium gates close and the potassium gates open. As positively charged potassium ions leave, the cell quickly begins repolarization. At first, it hyperpolarizes, becoming slightly more negative than the resting potential, and then it levels off, returning to the resting potential.<\/p>\r\n\r\n<div id=\"CNX_Psych_03_02_ActionP\" class=\"os-figure\">\r\n<figure>\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"487\"]<img id=\"48329\" src=\"https:\/\/openstax.org\/resources\/3d084f9cec67b33ae2c686fb2238e8ef9f1fe1f9\" alt=\"A graph shows the increase, peak, and decrease in membrane potential. The millivolts through the phases are approximately -70mV at resting potential, -55mV at threshold of excitation, 30mV at peak action potential, 5mV at repolarization, and -80mV at hyperpolarization.\" width=\"487\" height=\"352\" \/> Figure\u00a0BB.5\u00a0During the action potential, the electrical charge across the membrane changes dramatically.[\/caption]<\/figure>\r\n<\/div>\r\n<p id=\"fs-id1524038\" class=\"indent no-indent\">This positive spike constitutes the\u00a0<strong><span id=\"term152\">action potential<\/span>:<\/strong> the electrical signal that typically moves from the cell body down the axon to the axon terminals. The electrical signal moves down the axon with the impulses jumping in a leapfrog fashion between the Nodes of Ranvier. The Nodes of Ranvier are natural gaps in the myelin sheath. At each point, some of the sodium ions that enter the cell diffuse to the next section of the axon, raising the charge past the threshold of excitation and triggering a new influx of sodium ions. The action potential moves all the way down the axon in this fashion until reaching the terminal buttons.<\/p>\r\n<p id=\"fs-id1346901\">The action potential is an\u00a0<strong><span id=\"term153\">all-or-none<\/span><\/strong>\u00a0phenomenon. In simple terms, this means that an incoming signal from another neuron is either sufficient or insufficient to reach the threshold of excitation. There is no in-between, and there is no turning off an action potential once it starts. Think of it like sending an email or a text message. You can think about sending it all you want, but the message is not sent until you hit the send button. Furthermore, once you send the message, there is no stopping it.<\/p>\r\n<p id=\"fs-id1462453\">Because it is all or none, the\u00a0<span id=\"term154\" class=\"no-emphasis\">action potential<\/span>\u00a0is recreated, or propagated, at its full strength at every point along the axon. Much like the lit fuse of a firecracker, it does not fade away as it travels down the axon. It is this all-or-none property that explains the fact that your brain perceives an injury to a distant body part like your toe as equally painful as one to your nose.<\/p>\r\n<p id=\"fs-id1409574\">As noted earlier, when the action potential arrives at the terminal button, the synaptic vesicles release their neurotransmitters into the synaptic cleft. The neurotransmitters travel across the synapse and bind to receptors on the dendrites of the adjacent neuron, and the process repeats itself in the new neuron (assuming the signal is sufficiently strong to trigger an action potential). Once the signal is delivered, excess neurotransmitters in the synaptic cleft drift away, are broken down into inactive fragments, or are reabsorbed in a process known as\u00a0<strong><span id=\"term155\">reuptake<\/span><\/strong>. Reuptake involves the neurotransmitter being pumped back into the neuron that released it, in order to clear the synapse (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_Reuptake\">Figure BB.6<\/a>). Clearing the synapse serves both to provide a clear \u201con\u201d and \u201coff\u201d state between signals and to regulate the production of neurotransmitter (full synaptic vesicles provide signals that no additional neurotransmitters need to be produced). The synapse can also be cleared via <strong>degradation<\/strong> of the neurotransmitter, which typically involves an enzyme breaking the neurotransmitter down into it's components, so that it can no longer interact with the receptors on the postsynaptic neuron.<\/p>\r\n\r\n<div id=\"CNX_Psych_03_02_Reuptake\" class=\"os-figure\">\r\n<figure>\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"649\"]<img id=\"59801\" src=\"https:\/\/openstax.org\/resources\/5702a778859ad92103597c3eae5b473b388b3791\" alt=\"The synaptic space between two neurons is shown. Some neurotransmitters that have been released into the synapse are attaching to receptors while others undergo reuptake into the axon terminal.\" width=\"649\" height=\"418\" \/> Figure BB.6\u00a0Reuptake involves moving a neurotransmitter from the synapse back into the axon terminal from which it was released.[\/caption]<\/figure>\r\n<p class=\"os-caption-container indent no-indent\"><span style=\"text-align: initial;font-size: 1em\">Neuronal communication is often referred to as an electrochemical event. The movement of the action potential down the length of the axon is an electrical event, and movement of the neurotransmitter across the synaptic space represents the chemical portion of the process. However, there are some specialized connections between neurons that are entirely electrical. In such cases, the neurons are said to communicate via an electrical synapse. In these cases, two neurons physically connect to one another via gap junctions, which allows the current from one cell to pass into the next. There are far fewer electrical synapses in the brain, but those that do exist are much faster than the chemical synapses that have been described above (Connors &amp; Long, 2004).<\/span><\/p>\r\n&nbsp;\r\n\r\n<\/div>\r\n<\/section><section id=\"fs-id1470001\"><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTactionpotentials\"><\/a>TRICKY TOPIC: ACTION POTENTIALS\r\n<\/strong>[embed]https:\/\/youtu.be\/vWSmSIQbO0Q[\/embed]\r\n<p id=\"fs-id1565745\"><strong style=\"text-align: initial;font-size: 1em\">\u00a0<\/strong><\/p>\r\n\r\n<\/section><section id=\"fs-id1470001\"><em><span id=\"term70\">If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/vWSmSIQbO0Q\">https:\/\/youtu.be\/vWSmSIQbO0Q<\/a><\/span><\/em><\/section><section><em><span id=\"term70\">For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#actionpotentials\">here<\/a><\/span><\/em><\/section><section><\/section>\r\n<h3><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1em;font-weight: bold\">Neurotransmitters and Drugs<\/span><\/h3>\r\n<section id=\"fs-id1408486\">\r\n<p id=\"fs-id1435991\" class=\"indent no-indent\">There are several different types of\u00a0<span id=\"term156\" class=\"no-emphasis\">neurotransmitters<\/span>\u00a0released by different neurons, and we can speak in broad terms about the kinds of functions associated with different neurotransmitters (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#fs-id1346979\">Table BB.1<\/a>). Much of what psychologists know about the functions of neurotransmitters comes from research on the effects of drugs in psychological disorders. Psychologists who take a\u00a0<strong><span id=\"term157\">biological perspective<\/span>\u00a0<\/strong>and focus on the physiological causes of behaviour assert that psychological disorders like depression and schizophrenia are associated with imbalances in one or more neurotransmitter systems. In this perspective, psychotropic medications can help improve the symptoms associated with these disorders.\u00a0<strong><span id=\"term158\">Psychotropic medications<\/span>\u00a0<\/strong>are drugs that treat psychiatric symptoms by restoring neurotransmitter balance.<\/p>\r\n\r\n<div id=\"fs-id1346979\" class=\"os-table\">\r\n<table class=\"top-titled\" summary=\"Table 3.1 \">\r\n<thead>\r\n<tr>\r\n<th colspan=\"3\" scope=\"col\">Table BB.1 Major Neurotransmitters and How They Affect Behaviour<\/th>\r\n<\/tr>\r\n<tr>\r\n<th scope=\"col\">Neurotransmitter<\/th>\r\n<th scope=\"col\">Involved in<\/th>\r\n<th scope=\"col\">Potential Effect on Behaviour<\/th>\r\n<\/tr>\r\n<\/thead>\r\n<tbody>\r\n<tr>\r\n<td>Acetylcholine<\/td>\r\n<td>Muscle action, memory<\/td>\r\n<td>Increased arousal, enhanced cognition<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Beta-endorphin<\/td>\r\n<td>Pain, pleasure<\/td>\r\n<td>Decreased anxiety, decreased tension<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Dopamine<\/td>\r\n<td>Mood, sleep, learning<\/td>\r\n<td>Increased pleasure, suppressed appetite<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Gamma-aminobutyric acid (GABA)<\/td>\r\n<td>Brain function, sleep<\/td>\r\n<td>Decreased anxiety, decreased tension<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Glutamate<\/td>\r\n<td>Memory, learning<\/td>\r\n<td>Increased learning, enhanced memory<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Norepinephrine<\/td>\r\n<td>Heart, intestines, alertness<\/td>\r\n<td>Increased arousal, suppressed appetite<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>Serotonin<\/td>\r\n<td>Mood, sleep<\/td>\r\n<td>Modulated mood, suppressed appetite<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<p class=\"os-caption-container no-indent\"><span style=\"text-align: initial;font-size: 1em\">Psychoactive drugs can act as agonists or antagonists for a given neurotransmitter system.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term159\">Agonists<\/span>\u00a0<\/strong><span style=\"text-align: initial;font-size: 1em\">are chemicals that mimic a neurotransmitter at the receptor site. An\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term160\">antagonist<\/span><\/strong><span style=\"text-align: initial;font-size: 1em\">, on the other hand, blocks or impedes the normal activity of a neurotransmitter at the receptor. Agonists and antagonists represent drugs that are prescribed to correct the specific neurotransmitter imbalances underlying a person\u2019s condition. For example, Parkinson's disease, a progressive nervous system disorder, is associated with low levels of dopamine. Therefore, a common treatment strategy for Parkinson's disease involves using dopamine agonists, which mimic the effects of dopamine by binding to dopamine receptors.<\/span><\/p>\r\n\r\n<\/div>\r\n<p id=\"fs-id1392288\" class=\"no-indent\">Certain symptoms of schizophrenia are associated with overactive dopamine neurotransmission. The antipsychotics used to treat these symptoms are antagonists for dopamine\u2014they block dopamine\u2019s effects by binding its receptors without activating them. Thus, they prevent dopamine released by one neuron from signalling information to adjacent neurons.<\/p>\r\n<p id=\"fs-id1513352\">In contrast to agonists and antagonists, which both operate by binding to receptor sites, reuptake inhibitors prevent unused neurotransmitters from being transported back to the neuron. This allows neurotransmitters to remain active in the synaptic cleft for longer durations, increasing their effectiveness. Depression, which has been consistently linked with reduced serotonin levels, is commonly treated with selective serotonin reuptake inhibitors (SSRIs). By preventing reuptake, SSRIs strengthen the effect of serotonin, giving it more time to interact with serotonin receptors on dendrites. Common SSRIs on the market today include Prozac, Paxil, and Zoloft. The drug LSD is structurally very similar to serotonin, and it affects the same neurons and receptors as serotonin. Psychotropic drugs are not instant solutions for people suffering from psychological disorders. Often, an individual must take a drug for several weeks before seeing improvement, and many psychoactive drugs have significant negative side effects. Furthermore, individuals vary dramatically in how they respond to the drugs. To improve chances for success, it is not uncommon for people receiving pharmacotherapy to undergo psychological and\/or behavioural therapies as well. Some research suggests that combining drug therapy with other forms of therapy tends to be more effective than any one treatment alone (for one such example, see March et al., 2007).<\/p>\r\n\r\n<\/section><\/div>\r\n<\/div>\r\n<\/div>","rendered":"<div class=\"PageContent-ny9bj0-0 iapMdy\">\n<div id=\"main-content\" class=\"MainContent__HideOutline-sc-6yy1if-0 bdVAq\">\n<div id=\"cec4ceec-8232-473d-b4b7-405524a93eac\">\n<div id=\"41033\" class=\"ui-has-child-title\">\n<header>\n<div class=\"textbox textbox--learning-objectives\"><\/div>\n<\/header>\n<header class=\"textbox__header\">\n<p class=\"textbox__title\"><span style=\"color: #ffffff\">Learning Objectives<\/span><\/p>\n<\/header>\n<div class=\"textbox__content\">\n<section>By the end of this section, you will be able to:<\/p>\n<ul>\n<li>Identify the basic parts of a neuron<\/li>\n<li>Describe how neurons communicate with each other<\/li>\n<li>Explain how drugs act as agonists or antagonists for a given neurotransmitter system<\/li>\n<\/ul>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"fs-id1365204\" class=\"indent no-indent\">Psychologists striving to understand the human mind may study the nervous system. Learning how the body&#8217;s cells and organs function can help us understand the biological basis of human psychology. The\u00a0<strong><span id=\"term132\">nervous system<\/span><\/strong>\u00a0is composed of two basic cell types: glial cells (also known as glia) and neurons. <strong>Glial cells<\/strong> are traditionally thought to play a supportive role to neurons, both physically and metabolically.\u00a0<span id=\"term133\">Glial cells<\/span>\u00a0provide scaffolding on which the nervous system is built, help neurons line up closely with each other to allow neuronal communication, provide insulation to neurons, transport nutrients and waste products, and mediate immune responses. For years, researchers believed that there were many more glial cells than neurons; however, more recent work from Suzanna Herculano-Houzel&#8217;s laboratory has called this long-standing assumption into question and has provided important evidence that there may be a nearly 1:1 ratio of glia cells to neurons. This is important because it suggests that human brains are more similar to other primate brains than previously thought (Azevedo et al, 2009; Hercaulano-Houzel, 2012; Herculano-Houzel, 2009).\u00a0<strong><span id=\"term134\">Neurons<\/span><\/strong>, on the other hand, serve as interconnected information processors that are essential for all of the tasks of the nervous system. This section briefly describes the structure and function of neurons.<\/p>\n<section id=\"fs-id1470001\">\n<h3>Neuron Structure<\/h3>\n<p id=\"fs-id1577075\" class=\"indent no-indent\"><span id=\"term135\" class=\"no-emphasis\">Neurons<\/span>\u00a0are the central building blocks of the nervous system, 100 billion strong at birth. Like all cells, neurons consist of several different parts, each serving a specialized function (<a class=\"autogenerated-content\" href=\"http:\/\/www.mollywellsart.ca\/scientific-illustration.html\">Figure BB.2<\/a>). A neuron\u2019s outer surface is made up of a<strong>\u00a0<span id=\"term136\">semipermeable membrane<\/span><\/strong>. This membrane allows smaller molecules and molecules without an electrical charge to pass through it, while stopping larger or highly charged molecules.<\/p>\n<div id=\"CNX_Psych_03_02_Neuron\" class=\"os-figure\">\n<figure>\n<figure id=\"attachment_1406\" aria-describedby=\"caption-attachment-1406\" style=\"width: 1024px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1406 size-large\" src=\"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-1024x741.jpg\" alt=\"An illustration shows a neuron with labeled parts for the cell membrane, dendrite, cell body, axon, and terminal buttons. A myelin sheath covers part of the neuron.\" width=\"1024\" height=\"741\" srcset=\"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-1024x741.jpg 1024w, https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-300x217.jpg 300w, https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-768x556.jpg 768w, https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-65x47.jpg 65w, https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-225x163.jpg 225w, https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-content\/uploads\/sites\/21\/2020\/04\/neuron-structure-image-350x253.jpg 350w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption id=\"caption-attachment-1406\" class=\"wp-caption-text\">Figure BB.2 This illustration shows a prototypical neuron, which is being myelinated by a glial cell. (credit: <a href=\"http:\/\/www.mollywellsart.ca\/scientific-illustration.html\">Molly Wells Art<\/a>)<\/figcaption><\/figure>\n<\/figure>\n<p id=\"fs-id1456894\" class=\"indent no-indent\">The nucleus of the neuron is located in the\u00a0<strong><span id=\"term137\">soma<\/span>,<\/strong> or cell body. The soma has branching extensions known as\u00a0<strong><span id=\"term138\">dendrites<\/span><\/strong>. The neuron is a small information processor, and dendrites serve as input sites where signals are received from other neurons. These signals are transmitted electrically across the soma and down a major extension from the soma known as the\u00a0<strong><span id=\"term139\">axon<\/span><\/strong>, which ends at multiple<strong>\u00a0<span id=\"term140\">terminal buttons<\/span><\/strong>. The terminal buttons contain\u00a0<strong><span id=\"term141\">synaptic vesicles<\/span><\/strong>\u00a0that house\u00a0<strong><span id=\"term142\">neurotransmitters<\/span><\/strong>, the chemical messengers of the nervous system.<\/p>\n<p id=\"fs-id1565745\">Axons range in length from a fraction of an inch to several feet. In some axons, glial cells form a fatty substance known as the\u00a0<strong><span id=\"term143\">myelin sheath<\/span><\/strong>, which coats the axon and acts as an insulator, increasing the speed at which the signal travels. The myelin sheath is not continuous and there are small gaps that occur down the length of the axon. These gaps in the myelin sheath are known as the\u00a0<strong><span id=\"term144\">Nodes of Ranvier<\/span><\/strong>. The myelin sheath is crucial for the normal operation of the neurons within the nervous system: the loss of the insulation it provides can be detrimental to normal function. To understand how this works, let\u2019s consider an example. Phenylketonuria (fen-ul-key-toe-NU-ree-uh), also called PKU, causes a reduction in myelin and abnormalities in white matter cortical and subcortical structures. The disorder is associated with a variety of issues including severe cognitive deficits, exaggerated reflexes, and seizures (Anderson &amp; Leuzzi, 2010; Huttenlocher, 2000). Another disorder, multiple sclerosis (MS), an autoimmune disorder, involves a large-scale loss of the myelin sheath on axons throughout the nervous system. The resulting interference in the electrical signal prevents the quick transmittal of information by neurons and can lead to a number of symptoms, such as dizziness, fatigue, loss of motor control, and sexual dysfunction. While some treatments may help to modify the course of the disease and manage certain symptoms, there is currently no known cure for multiple sclerosis.<\/p>\n<p class=\"no-indent\"><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTneuronalstructure\"><\/a>TRICKY TOPIC: NEURONAL STRUCTURE<br \/>\n<\/strong><\/p>\n<p><iframe loading=\"lazy\" id=\"oembed-1\" title=\"Tricky Topics: NeuronalStructure\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/zpWZ5PgZFF0?feature=oembed&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><em><span style=\"font-size: 1em\">If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/zpWZ5PgZFF0\">https:\/\/youtu.be\/zpWZ5PgZFF0<\/a><\/span><\/em><\/p>\n<\/div>\n<\/section>\n<section><em><span id=\"term70\">For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#neuronalstructure\">here<\/a><\/span><\/em><\/section>\n<section><\/section>\n<section>\n<p id=\"fs-id1577995\">In healthy individuals, the neuronal signal moves rapidly down the axon to the terminal buttons, where synaptic vesicles release neurotransmitters into the <strong>synaptic cleft<\/strong> (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_Synapse\">Figure BB.3<\/a>). The\u00a0<span id=\"term145\">synaptic cleft<\/span>\u00a0is a very small space between two neurons and is an important site where communication between neurons occurs. Once neurotransmitters are released into the synaptic cleft, they travel across it and bind with corresponding receptors on the dendrite of an adjacent neuron.<strong>\u00a0<span id=\"term146\">Receptors<\/span>,<\/strong> proteins on the cell surface where neurotransmitters attach, vary in shape, with different shapes \u201cmatching\u201d different neurotransmitters.<\/p>\n<p id=\"eip-772\">How does a neurotransmitter \u201cknow\u201d which receptor to bind to? The neurotransmitter and the receptor have what is referred to as a lock-and-key relationship\u2014specific neurotransmitters fit specific receptors similar to how a key fits a lock. The neurotransmitter binds to any receptor that it fits.<\/p>\n<div id=\"CNX_Psych_03_02_Synapse\" class=\"os-figure\">\n<figure>\n<figure style=\"width: 976px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" id=\"54888\" src=\"https:\/\/openstax.org\/resources\/19b96297b4eb951260d2140515a3e7261f82d331\" alt=\"Image (a) shows the synaptic space between two neurons, with neurotransmitters being released into the synapse and attaching to receptors. Image (b) is a micrograph showing a spherical terminal button with part of the exterior removed, revealing a solid interior of small round parts.\" width=\"976\" height=\"428\" \/><figcaption class=\"wp-caption-text\">Figure BB.3 (a) The synaptic cleft is the space between the terminal button of one neuron and the dendrite of another neuron. (b) In this pseudo-colored image from a scanning electron microscope, a terminal button (green) has been opened to reveal the synaptic vesicles (orange and blue) inside. Each vesicle contains about 10,000 neurotransmitter molecules. (credit b: modification of work by Tina Carvalho, NIH-NIGMS; scale-bar data from Matt Russell)<\/figcaption><\/figure>\n<\/figure>\n<\/div>\n<\/section>\n<section>\n<section><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTsyntransmission\"><\/a>TRICKY TOPIC: SYNAPTIC TRANSMISSION<br \/>\n<\/strong><iframe loading=\"lazy\" id=\"oembed-2\" title=\"Tricky Topics: Synaptic Transmission\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/M7OMTco-qV4?feature=oembed&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><em style=\"font-size: 1em\"><span>If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/M7OMTco-qV4\">https:\/\/youtu.be\/M7OMTco-qV4<\/a><\/span><\/em><\/p>\n<\/section>\n<section><em><span>For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#syntransmission\">here<\/a><\/span><\/em><\/section>\n<h3>Neuronal Communication<\/h3>\n<p id=\"fs-id1560860\">Now that we have learned about the basic structures of the neuron and the role that these structures play in neuronal communication, let\u2019s take a closer look at the signal itself\u2014how it moves through the neuron and then jumps to the next neuron, where the process is repeated.<\/p>\n<p id=\"fs-id1500598\">We begin at the neuronal membrane. The\u00a0<span id=\"term147\" class=\"no-emphasis\">neuron<\/span>\u00a0exists in a fluid environment\u2014it is surrounded by extracellular fluid and contains intracellular fluid (i.e., cytoplasm). The neuronal membrane keeps these two fluids separate\u2014a critical role because the electrical signal that passes through the neuron depends on the intra- and extracellular fluids being electrically different. This difference in charge across the membrane, called the\u00a0<strong><span id=\"term148\">membrane potential<\/span><\/strong>, provides energy for the signal.<\/p>\n<p id=\"fs-id1561065\">The electrical charge of the fluids is caused by charged molecules (ions) dissolved in the fluid. The semipermeable nature of the neuronal membrane somewhat restricts the movement of these charged molecules, and, as a result, some of the charged particles tend to become more concentrated either inside or outside the cell.<\/p>\n<p id=\"fs-id1470173\">Between signals, the neuron membrane\u2019s potential is held in a state of readiness, called the\u00a0<strong><span id=\"term149\">resting potential<\/span>.<\/strong>\u00a0The typical resting potential of a neuron is -70 mV. Like a rubber band stretched out and waiting to spring into action, ions line up on either side of the cell membrane, ready to rush across the membrane when the neuron goes active and the membrane opens its gates (i.e., a\u00a0<span id=\"term150\" class=\"no-emphasis\">sodium-potassium pump<\/span>\u00a0that allows movement of ions across the membrane). Ions in high-concentration areas are ready to move to low-concentration areas, and positive ions are ready to move to areas with a negative charge.<\/p>\n<p id=\"fs-id1574264\">In the resting state, sodium (Na<sup>+<\/sup>) is at higher concentrations outside the cell, so it will tend to move into the cell. Potassium (K<sup>+<\/sup>), on the other hand, is more concentrated inside the cell, and will tend to move out of the cell (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_NaKConc\">Figure BB.4<\/a>). In addition, the inside of the cell is slightly negatively charged compared to the outside. This difference in charge, known as the\u00a0<strong>electrochemical gradient,<\/strong>\u00a0provides an additional force on sodium, causing it to move into the cell.<\/p>\n<div id=\"CNX_Psych_03_02_NaKConc\" class=\"os-figure\">\n<figure>\n<figure style=\"width: 975px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" id=\"68934\" src=\"https:\/\/openstax.org\/resources\/64f9607dcac413179b9f7d0f596305bab38f3800\" alt=\"A close-up illustration depicts the difference in charges across the cell membrane, and shows how Na+ and K+ cells concentrate more closely near the membrane.\" width=\"975\" height=\"368\" \/><figcaption class=\"wp-caption-text\">Figure BB.4\u00a0At resting potential, Na+\u00a0(blue pentagons) is more highly concentrated outside the cell in the extracellular fluid (shown in blue), whereas K+\u00a0(purple squares) is more highly concentrated near the membrane in the cytoplasm or intracellular fluid. Other molecules, such as chloride ions (yellow circles) and negatively charged proteins (brown squares), help contribute to a positive net charge in the extracellular fluid and a negative net charge in the intracellular fluid.<\/figcaption><\/figure>\n<\/figure>\n<p class=\"os-caption-container\"><span style=\"text-align: initial;font-size: 1em\">From this resting potential state, the neuron receives a signal and its state changes abruptly (<\/span><a class=\"autogenerated-content\" style=\"text-align: initial;font-size: 1em\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_ActionP\">Figure BB.5<\/a><span style=\"text-align: initial;font-size: 1em\">). When a neuron receives signals at the dendrites\u2014due to neurotransmitters from an adjacent neuron binding to its receptors\u2014small pores, or gates, open on the neuronal membrane, allowing Na<\/span><sup style=\"text-align: initial\">+<\/sup><span style=\"text-align: initial;font-size: 1em\">\u00a0ions, propelled by both charge and concentration differences, to move into the cell. With this influx of positive ions, the internal charge of the cell becomes more positive. If that charge reaches a certain level, called the\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term151\">threshold of excitation<\/span><\/strong><span style=\"text-align: initial;font-size: 1em\">, the neuron becomes active and the action potential begins.<\/span><\/p>\n<\/div>\n<p id=\"eip-267\">Many additional pores open, causing a massive influx of Na<sup>+<\/sup>\u00a0ions and a huge positive spike in the membrane potential, the peak action potential. At the peak of the spike, the sodium gates close and the potassium gates open. As positively charged potassium ions leave, the cell quickly begins repolarization. At first, it hyperpolarizes, becoming slightly more negative than the resting potential, and then it levels off, returning to the resting potential.<\/p>\n<div id=\"CNX_Psych_03_02_ActionP\" class=\"os-figure\">\n<figure>\n<figure style=\"width: 487px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" id=\"48329\" src=\"https:\/\/openstax.org\/resources\/3d084f9cec67b33ae2c686fb2238e8ef9f1fe1f9\" alt=\"A graph shows the increase, peak, and decrease in membrane potential. The millivolts through the phases are approximately -70mV at resting potential, -55mV at threshold of excitation, 30mV at peak action potential, 5mV at repolarization, and -80mV at hyperpolarization.\" width=\"487\" height=\"352\" \/><figcaption class=\"wp-caption-text\">Figure\u00a0BB.5\u00a0During the action potential, the electrical charge across the membrane changes dramatically.<\/figcaption><\/figure>\n<\/figure>\n<\/div>\n<p id=\"fs-id1524038\" class=\"indent no-indent\">This positive spike constitutes the\u00a0<strong><span id=\"term152\">action potential<\/span>:<\/strong> the electrical signal that typically moves from the cell body down the axon to the axon terminals. The electrical signal moves down the axon with the impulses jumping in a leapfrog fashion between the Nodes of Ranvier. The Nodes of Ranvier are natural gaps in the myelin sheath. At each point, some of the sodium ions that enter the cell diffuse to the next section of the axon, raising the charge past the threshold of excitation and triggering a new influx of sodium ions. The action potential moves all the way down the axon in this fashion until reaching the terminal buttons.<\/p>\n<p id=\"fs-id1346901\">The action potential is an\u00a0<strong><span id=\"term153\">all-or-none<\/span><\/strong>\u00a0phenomenon. In simple terms, this means that an incoming signal from another neuron is either sufficient or insufficient to reach the threshold of excitation. There is no in-between, and there is no turning off an action potential once it starts. Think of it like sending an email or a text message. You can think about sending it all you want, but the message is not sent until you hit the send button. Furthermore, once you send the message, there is no stopping it.<\/p>\n<p id=\"fs-id1462453\">Because it is all or none, the\u00a0<span id=\"term154\" class=\"no-emphasis\">action potential<\/span>\u00a0is recreated, or propagated, at its full strength at every point along the axon. Much like the lit fuse of a firecracker, it does not fade away as it travels down the axon. It is this all-or-none property that explains the fact that your brain perceives an injury to a distant body part like your toe as equally painful as one to your nose.<\/p>\n<p id=\"fs-id1409574\">As noted earlier, when the action potential arrives at the terminal button, the synaptic vesicles release their neurotransmitters into the synaptic cleft. The neurotransmitters travel across the synapse and bind to receptors on the dendrites of the adjacent neuron, and the process repeats itself in the new neuron (assuming the signal is sufficiently strong to trigger an action potential). Once the signal is delivered, excess neurotransmitters in the synaptic cleft drift away, are broken down into inactive fragments, or are reabsorbed in a process known as\u00a0<strong><span id=\"term155\">reuptake<\/span><\/strong>. Reuptake involves the neurotransmitter being pumped back into the neuron that released it, in order to clear the synapse (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#CNX_Psych_03_02_Reuptake\">Figure BB.6<\/a>). Clearing the synapse serves both to provide a clear \u201con\u201d and \u201coff\u201d state between signals and to regulate the production of neurotransmitter (full synaptic vesicles provide signals that no additional neurotransmitters need to be produced). The synapse can also be cleared via <strong>degradation<\/strong> of the neurotransmitter, which typically involves an enzyme breaking the neurotransmitter down into it&#8217;s components, so that it can no longer interact with the receptors on the postsynaptic neuron.<\/p>\n<div id=\"CNX_Psych_03_02_Reuptake\" class=\"os-figure\">\n<figure>\n<figure style=\"width: 649px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" id=\"59801\" src=\"https:\/\/openstax.org\/resources\/5702a778859ad92103597c3eae5b473b388b3791\" alt=\"The synaptic space between two neurons is shown. Some neurotransmitters that have been released into the synapse are attaching to receptors while others undergo reuptake into the axon terminal.\" width=\"649\" height=\"418\" \/><figcaption class=\"wp-caption-text\">Figure BB.6\u00a0Reuptake involves moving a neurotransmitter from the synapse back into the axon terminal from which it was released.<\/figcaption><\/figure>\n<\/figure>\n<p class=\"os-caption-container indent no-indent\"><span style=\"text-align: initial;font-size: 1em\">Neuronal communication is often referred to as an electrochemical event. The movement of the action potential down the length of the axon is an electrical event, and movement of the neurotransmitter across the synaptic space represents the chemical portion of the process. However, there are some specialized connections between neurons that are entirely electrical. In such cases, the neurons are said to communicate via an electrical synapse. In these cases, two neurons physically connect to one another via gap junctions, which allows the current from one cell to pass into the next. There are far fewer electrical synapses in the brain, but those that do exist are much faster than the chemical synapses that have been described above (Connors &amp; Long, 2004).<\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/section>\n<section><strong style=\"text-align: initial;font-size: 1em\"><a id=\"TTactionpotentials\"><\/a>TRICKY TOPIC: ACTION POTENTIALS<br \/>\n<\/strong><iframe loading=\"lazy\" id=\"oembed-3\" title=\"Tricky Topics: Action Potentials\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/vWSmSIQbO0Q?feature=oembed&#38;rel=0\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><strong style=\"text-align: initial;font-size: 1em\">\u00a0<\/strong><\/p>\n<\/section>\n<section><em><span>If the video above does not load, click here:\u00a0<a href=\"https:\/\/youtu.be\/vWSmSIQbO0Q\">https:\/\/youtu.be\/vWSmSIQbO0Q<\/a><\/span><\/em><\/section>\n<section><em><span>For a full transcript of this video, click <a href=\"\/intropsychneuro\/back-matter\/appendix\/#actionpotentials\">here<\/a><\/span><\/em><\/section>\n<section><\/section>\n<h3><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1em;font-weight: bold\">Neurotransmitters and Drugs<\/span><\/h3>\n<section id=\"fs-id1408486\">\n<p id=\"fs-id1435991\" class=\"indent no-indent\">There are several different types of\u00a0<span id=\"term156\" class=\"no-emphasis\">neurotransmitters<\/span>\u00a0released by different neurons, and we can speak in broad terms about the kinds of functions associated with different neurotransmitters (<a class=\"autogenerated-content\" href=\"https:\/\/openstax.org\/books\/psychology-2e\/pages\/3-2-cells-of-the-nervous-system#fs-id1346979\">Table BB.1<\/a>). Much of what psychologists know about the functions of neurotransmitters comes from research on the effects of drugs in psychological disorders. Psychologists who take a\u00a0<strong><span id=\"term157\">biological perspective<\/span>\u00a0<\/strong>and focus on the physiological causes of behaviour assert that psychological disorders like depression and schizophrenia are associated with imbalances in one or more neurotransmitter systems. In this perspective, psychotropic medications can help improve the symptoms associated with these disorders.\u00a0<strong><span id=\"term158\">Psychotropic medications<\/span>\u00a0<\/strong>are drugs that treat psychiatric symptoms by restoring neurotransmitter balance.<\/p>\n<div id=\"fs-id1346979\" class=\"os-table\">\n<table class=\"top-titled\" summary=\"Table 3.1\">\n<thead>\n<tr>\n<th colspan=\"3\" scope=\"col\">Table BB.1 Major Neurotransmitters and How They Affect Behaviour<\/th>\n<\/tr>\n<tr>\n<th scope=\"col\">Neurotransmitter<\/th>\n<th scope=\"col\">Involved in<\/th>\n<th scope=\"col\">Potential Effect on Behaviour<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Acetylcholine<\/td>\n<td>Muscle action, memory<\/td>\n<td>Increased arousal, enhanced cognition<\/td>\n<\/tr>\n<tr>\n<td>Beta-endorphin<\/td>\n<td>Pain, pleasure<\/td>\n<td>Decreased anxiety, decreased tension<\/td>\n<\/tr>\n<tr>\n<td>Dopamine<\/td>\n<td>Mood, sleep, learning<\/td>\n<td>Increased pleasure, suppressed appetite<\/td>\n<\/tr>\n<tr>\n<td>Gamma-aminobutyric acid (GABA)<\/td>\n<td>Brain function, sleep<\/td>\n<td>Decreased anxiety, decreased tension<\/td>\n<\/tr>\n<tr>\n<td>Glutamate<\/td>\n<td>Memory, learning<\/td>\n<td>Increased learning, enhanced memory<\/td>\n<\/tr>\n<tr>\n<td>Norepinephrine<\/td>\n<td>Heart, intestines, alertness<\/td>\n<td>Increased arousal, suppressed appetite<\/td>\n<\/tr>\n<tr>\n<td>Serotonin<\/td>\n<td>Mood, sleep<\/td>\n<td>Modulated mood, suppressed appetite<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"os-caption-container no-indent\"><span style=\"text-align: initial;font-size: 1em\">Psychoactive drugs can act as agonists or antagonists for a given neurotransmitter system.\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term159\">Agonists<\/span>\u00a0<\/strong><span style=\"text-align: initial;font-size: 1em\">are chemicals that mimic a neurotransmitter at the receptor site. An\u00a0<\/span><strong style=\"text-align: initial;font-size: 1em\"><span id=\"term160\">antagonist<\/span><\/strong><span style=\"text-align: initial;font-size: 1em\">, on the other hand, blocks or impedes the normal activity of a neurotransmitter at the receptor. Agonists and antagonists represent drugs that are prescribed to correct the specific neurotransmitter imbalances underlying a person\u2019s condition. For example, Parkinson&#8217;s disease, a progressive nervous system disorder, is associated with low levels of dopamine. Therefore, a common treatment strategy for Parkinson&#8217;s disease involves using dopamine agonists, which mimic the effects of dopamine by binding to dopamine receptors.<\/span><\/p>\n<\/div>\n<p id=\"fs-id1392288\" class=\"no-indent\">Certain symptoms of schizophrenia are associated with overactive dopamine neurotransmission. The antipsychotics used to treat these symptoms are antagonists for dopamine\u2014they block dopamine\u2019s effects by binding its receptors without activating them. Thus, they prevent dopamine released by one neuron from signalling information to adjacent neurons.<\/p>\n<p id=\"fs-id1513352\">In contrast to agonists and antagonists, which both operate by binding to receptor sites, reuptake inhibitors prevent unused neurotransmitters from being transported back to the neuron. This allows neurotransmitters to remain active in the synaptic cleft for longer durations, increasing their effectiveness. Depression, which has been consistently linked with reduced serotonin levels, is commonly treated with selective serotonin reuptake inhibitors (SSRIs). By preventing reuptake, SSRIs strengthen the effect of serotonin, giving it more time to interact with serotonin receptors on dendrites. Common SSRIs on the market today include Prozac, Paxil, and Zoloft. The drug LSD is structurally very similar to serotonin, and it affects the same neurons and receptors as serotonin. Psychotropic drugs are not instant solutions for people suffering from psychological disorders. Often, an individual must take a drug for several weeks before seeing improvement, and many psychoactive drugs have significant negative side effects. Furthermore, individuals vary dramatically in how they respond to the drugs. To improve chances for success, it is not uncommon for people receiving pharmacotherapy to undergo psychological and\/or behavioural therapies as well. Some research suggests that combining drug therapy with other forms of therapy tends to be more effective than any one treatment alone (for one such example, see March et al., 2007).<\/p>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"author":13,"menu_order":2,"template":"","meta":{"pb_show_title":"on","pb_short_title":"","pb_subtitle":"","pb_authors":[],"pb_section_license":""},"chapter-type":[],"contributor":[],"license":[],"part":23,"_links":{"self":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapters\/93"}],"collection":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/wp\/v2\/users\/13"}],"version-history":[{"count":32,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapters\/93\/revisions"}],"predecessor-version":[{"id":2118,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapters\/93\/revisions\/2118"}],"part":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/parts\/23"}],"metadata":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapters\/93\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/pressbooks\/v2\/chapter-type?post=93"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/wp\/v2\/contributor?post=93"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/digitaleditions.library.dal.ca\/intropsychneuro\/wp-json\/wp\/v2\/license?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}