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20 The Brain and Spinal Cord

Learning Objectives

By the end of this section, you will be able to:

  • Explain the functions of the spinal cord
  • Identify the hemispheres and lobes of the brain
  • Describe the types of techniques available to clinicians and researchers to image or scan the brain

The brain is a remarkably complex organ comprised of billions of interconnected neurones and glia. It is a bilateral, or two-sided, structure that can be separated into distinct lobes. Each lobe is associated with certain types of functions, but, ultimately, all of the areas of the brain interact with one another to provide the foundation for our thoughts and behaviours. In this section, we discuss the overall organization of the brain and the functions associated with different brain areas, beginning with what can be seen as an extension of the brain, the spinal cord.

The Spinal Cord

It can be said that the spinal cord is what connects the brain to the outside world. Because of it, the brain can act. The spinal cord is like a relay station, but a very smart one. It not only routes messages to and from the brain, but it also has its own system of automatic processes, called reflexes.

The top of the spinal cord is a bundle of nerves that merges with the brain stem, where the basic processes of life are controlled, such as breathing and digestion. In the opposite direction, the spinal cord ends just below the ribs—contrary to what we might expect, it does not extend all the way to the base of the spine.

The spinal cord is functionally organized in 30 segments, corresponding with the vertebrae. Each segment is connected to a specific part of the body through the peripheral nervous system. Nerves branch out from the spine at each vertebra. Sensory nerves bring messages in; motor nerves send messages out to the muscles and organs. Messages travel to and from the brain through every segment.

Some sensory messages are immediately acted on by the spinal cord, without any input from the brain. Withdrawal from a hot object and the knee jerk are two examples. When a sensory message meets certain parameters, the spinal cord initiates an automatic reflex. The signal passes from the sensory nerve to a simple processing centre, which initiates a motor command. Seconds are saved, because messages don’t have to go the brain, be processed, and get sent back. In matters of survival, the spinal reflexes allow the body to react extraordinarily fast.

The spinal cord is protected by bony vertebrae and cushioned in cerebrospinal fluid, but injuries still occur. When the spinal cord is damaged in a particular segment, all lower segments are cut off from the brain, causing paralysis. Therefore, the lower on the spine damage occurs, the fewer functions an injured individual will lose.

 

TRICKY TOPIC: CORTICAL ANATOMY

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Hindbrain Structures

The hindbrain is located at the back of the head and looks like an extension of the spinal cord. It contains the medulla, pons, and cerebellum (Figure BB.9). The medulla controls the automatic processes of the autonomic nervous system, such as breathing, blood pressure, and heart rate. The word pons literally means “bridge,” and as the name suggests, the pons serves to connect the hindbrain to the rest of the brain. It also is involved in regulating brain activity during sleep. The medulla, pons, and various structures are known as the brainstem, and aspects of the brainstem span both the midbrain and the hindbrain.

An illustration shows the location of the pons, medulla, and cerebellum.

Figure BB.9 The pons, medulla, and cerebellum make up the hindbrain.

The cerebellum (Latin for “little brain”) receives messages from muscles, tendons, joints, and structures in our ear to control balance, coordination, movement, and fine motor skills. The cerebellum is also thought to be an important area for processing some types of memories. In particular, procedural memory, or memory involved in learning and remembering how to perform tasks, is thought to be associated with the cerebellum. The case of H. M. is discussed below. When reading about this later, recall that H.M. was unable to form new explicit memories, but he could learn new tasks. This is likely due to the fact that H. M.’s cerebellum remained intact.

Midbrain Structures

The midbrain is comprised of structures located deep within the brain, between the forebrain and the hindbrain. The reticular formation is centred in the midbrain, but it actually extends up into the forebrain and down into the hindbrain. The reticular formation is important in regulating the sleep/wake cycle, arousal, alertness, and motor activity.

The substantia nigra (Latin for “black substance”) and the ventral tegmental area (VTA) are also located in the midbrain (Figure BB.10). Both regions contain cell bodies that produce the neurotransmitter dopamine, and both are critical for movement. Degeneration of the substantia nigra and VTA is involved in Parkinson’s disease. In addition, these structures are involved in mood, reward, and addiction (Berridge & Robinson, 1998; Gardner, 2011; George, Le Moal, & Koob, 2012).

An illustration shows the location of the substantia nigra and VTA in the brain.

Figure BB.10 The substantia nigra and ventral tegmental area (VTA) are located in the midbrain.

Forebrain Structures

The surface of the brain, known as the cerebral cortex, is very uneven, characterized by a distinctive pattern of folds or bumps, known as gyri (singular: gyrus), and grooves, known as sulci (singular: sulcus), shown in Figure BB.11. These gyri and sulci form important landmarks that allow us to separate the brain into functional centres. The most prominent sulcus, known as the longitudinal fissure, is the deep groove that separates the brain into two halves or hemispheres: the left hemisphere and the right hemisphere.

An illustration of the brain’s exterior surface shows the ridges and depressions, and the deep fissure that runs through the center.

Figure BB.11 The surface of the brain is covered with gyri and sulci. A deep sulcus is called a fissure, such as the longitudinal fissure that divides the brain into left and right hemispheres. (credit: modification of work by Bruce Blaus)

The two hemispheres of the cerebral cortex are part of the forebrain (Figure BB.12), which is the largest part of the brain. The forebrain contains the cerebral cortex and a number of other structures that lie beneath the cortex (called subcortical structures): thalamus, hypothalamus, pituitary gland, and the limbic system (a collection of structures). The cerebral cortex, which is the outer surface of the brain, is associated with higher level processes such as consciousness, thought, emotion, reasoning, language, and memory. Each cerebral hemisphere can be subdivided into four lobes, each associated with different functions.

An illustration shows the position and size of the forebrain (the largest portion), midbrain (a small central portion), and hindbrain (a portion in the lower back part of the brain).

Figure BB.12 The brain and its parts can be divided into three main categories: the forebrain, midbrain, and hindbrain.

Lobes of the Brain

The four lobes of the brain are the frontal, parietal, temporal, and occipital lobes (Figure BB.13). The frontal lobe is located in the forward part of the brain, extending back to a fissure known as the central sulcus. The frontal lobe is involved in reasoning, motor control, emotion, and language. It contains the motor cortex, which is involved in planning and coordinating movement; the prefrontal cortex, which is responsible for higher-level cognitive functioning; and Broca’s area, which is essential for language production.

An illustration shows the four lobes of the brain.

Figure BB.13 The lobes of the brain are shown.

People who suffer damage to Broca’s area have great difficulty producing language of any form (Figure BB.13). For example, Deepu was an electrical engineer who was socially active and a caring, involved parent. About twenty years ago, Deepu was in a car accident and suffered damage to their Broca’s area. Deepu completely lost the ability to speak and form any kind of meaningful language. There is nothing wrong with their mouth or vocal cords, but Deepu is unable to produce words. Deepu can follow directions but can’t respond verbally, and they can read but no longer write. They can do routine tasks like running to the market to buy milk, but they could not communicate verbally if a situation called for it.

Probably the most famous case of frontal lobe damage is that of a man by the name of Phineas Gage. On September 13, 1848, Gage (age 25) was working as a railroad foreman in Vermont. He and his crew were using an iron rod to tamp explosives down into a blasting hole to remove rock along the railway’s path. Unfortunately, the iron rod created a spark and caused the rod to explode out of the blasting hole, into Gage’s face, and through his skull (Figure BB.14). Although lying in a pool of his own blood with brain matter emerging from his head, Gage was conscious and able to get up, walk, and speak. But in the months following his accident, people noticed that his personality had changed. Many of his friends described him as no longer being himself. Before the accident, it was said that Gage was a well-mannered, soft-spoken man, but he began to behave in odd and inappropriate ways after the accident. Such changes in personality would be consistent with loss of impulse control—a frontal lobe function.

Beyond the damage to the frontal lobe itself, subsequent investigations into the rod’s path also identified probable damage to pathways between the frontal lobe and other brain structures, including the limbic system. With connections between the planning functions of the frontal lobe and the emotional processes of the limbic system severed, Gage had difficulty controlling his emotional impulses.

However, there is some evidence suggesting that the dramatic changes in Gage’s personality were exaggerated and embellished. Gage’s case occurred in the midst of a 19th century debate over localization—regarding whether certain areas of the brain are associated with particular functions. On the basis of extremely limited information about Gage, the extent of his injury, and his life before and after the accident, scientists tended to find support for their own views, on whichever side of the debate they fell (Macmillan, 1999).

Image (a) is a photograph of Phineas Gage holding a metal rod. Image (b) is an illustration of a skull with a metal rod passing through it from the cheek area to the top of the skull.

Figure BB.14 (a) Phineas Gage holds the iron rod that penetrated his skull in an 1848 railroad construction accident. (b) Gage’s prefrontal cortex was severely damaged in the left hemisphere. The rod entered Gage’s face on the left side, passed behind his eye, and exited through the top of his skull, before landing about 80 feet away. (credit a: modification of work by Jack and Beverly Wilgus)

The brain’s parietal lobe is located immediately behind the frontal lobe, and is involved in processing information from the body’s senses. It contains the somatosensory cortex, which is essential for processing sensory information from across the body, such as touch, temperature, and pain. The somatosensory cortex is organized topographically, which means that spatial relationships that exist in the body are generally maintained on the surface of the somatosensory cortex (Figure BB.15). For example, the portion of the cortex that processes sensory information from the hand is adjacent to the portion that processes information from the wrist.

A diagram shows the organization in the somatosensory cortex, with functions for these parts in this proximal sequential order: toes, ankles, knees, hips, trunk, shoulders, elbows, wrists, hands, fingers, thumbs, neck, eyebrows and eyelids, eyeballs, face, lips, jaw, tongue, salivation, chewing, and swallowing.

Figure BB.15 Spatial relationships in the body are mirrored in the organization of the somatosensory cortex.

The temporal lobe is located on the side of the head (temporal means “near the temples”), and is associated with hearing, memory, emotion, and some aspects of language. The auditory cortex, the main area responsible for processing auditory information, is located within the temporal lobe. Wernicke’s area, important for speech comprehension, is also located here. Whereas individuals with damage to Broca’s area have difficulty producing language, those with damage to Wernicke’s area can produce sensible language, but they are unable to understand it (Figure BB.16). Both Broca’s area and Wernicke’s area are located only in the left hemisphere.

An illustration shows the locations of Broca’s and Wernicke’s areas.

Figure BB.16 Damage to either Broca’s area or Wernicke’s area can result in language deficits. The types of deficits are very different, however, depending on which area is affected.

The occipital lobe is located at the very back of the brain, and contains the primary visual cortex, which is responsible for interpreting incoming visual information. The occipital cortex is organized retinotopically, which means there is a close relationship between the position of an object in a person’s visual field and the position of that object’s representation on the cortex. You will learn much more about how visual information is processed in the occipital lobe when you study sensation and perception.

Other Areas of the Forebrain

Other areas of the forebrain, located beneath the cerebral cortex, include the thalamus and the limbic system. The thalamus is a sensory relay for the brain. All of our senses, with the exception of smell, are routed through the thalamus before being directed to other areas of the brain for processing (Figure BB.17).

An illustration shows the location of the thalamus in the brain.

Figure BB.17 The thalamus serves as the relay centre of the brain where most senses are routed for processing.

The limbic system is involved in processing both emotion and memory. Interestingly, the sense of smell projects directly to the limbic system; therefore, not surprisingly, smell can evoke emotional responses in ways that other sensory modalities cannot. The limbic system is made up of a number of different structures, but three of the most important are the hippocampus, the amygdala, and the hypothalamus (Figure BB.18). The hippocampus is an essential structure for learning and memory. The amygdala is involved in our experience of emotion and in tying emotional meaning to our memories. The hypothalamus regulates a number of homeostatic processes, including the regulation of body temperature, appetite, and blood pressure. The hypothalamus also serves as an interface between the nervous system and the endocrine system and in the regulation of sexual motivation and behaviour.

An illustration shows the locations of parts of the brain involved in the limbic system: the hypothalamus, amygdala, and hippocampus.

Figure BB.18 The limbic system is involved in mediating emotional response and memory.

The Case of Henry Molaison (H.M.)

In 1953, Henry Gustav Molaison (H. M.) was a 27-year-old man who experienced severe seizures. In an attempt to control his seizures, H. M. underwent brain surgery to remove his hippocampus and amygdala. Following the surgery, H.M’s seizures became much less severe, but he also suffered some unexpected—and devastating—consequences of the surgery: he lost his ability to form many types of new memories. For example, he was unable to learn new facts, such as who was president of the United States. He was able to learn new skills, but afterward he had no recollection of learning them. For example, while he might learn to use a computer, he would have no conscious memory of ever having used one. He could not remember new faces, and he was unable to remember events, even immediately after they occurred. Researchers were fascinated by his experience, and he is considered one of the most studied cases in medical and psychological history (Hardt, Einarsson, & Nader, 2010; Squire, 2009). Indeed, his case has provided tremendous insight into the role that the hippocampus plays in the consolidation of new learning into explicit memory.

Lateralization

There is evidence of specialization of function—referred to as lateralization—in each hemisphere, mainly regarding differences in language functions. The left hemisphere controls the right half of the body, and the right hemisphere controls the left half of the body. Decades of research on lateralization of function by Michael Gazzaniga and his colleagues suggest that a variety of functions ranging from cause-and-effect reasoning to self-recognition may follow patterns that suggest some degree of hemispheric dominance (Gazzaniga, 2005). For example, the left hemisphere has been shown to be superior for forming associations in memory, selective attention, and positive emotions. The right hemisphere, on the other hand, has been shown to be superior in pitch perception, arousal, and negative emotions (Ehret, 2006). However, it should be pointed out that research on which hemisphere is dominant in a variety of different behaviours has produced inconsistent results, and therefore, it is probably better to think of how the two hemispheres interact to produce a given behaviour rather than attributing certain behaviours to one hemisphere versus the other (Banich & Heller, 1998).

The two hemispheres are connected by a thick band of neural fibres known as the corpus callosum, consisting of about 200 million axons. The corpus callosum allows the two hemispheres to communicate with each other and allows for information being processed on one side of the brain to be shared with the other side.

Normally, we are not aware of the different roles that our two hemispheres play in day-to-day functions, but there are people who come to know the capabilities and functions of their two hemispheres quite well. In some cases of severe epilepsy, doctors elect to sever the corpus callosum as a means of controlling the spread of seizures (Figure BB.19). While this is an effective treatment option, it results in individuals who have “split brains.” After surgery, these split-brain patients show a variety of interesting behaviours. For instance, a split-brain patient is unable to name a picture that is shown in the patient’s left visual field because the information is only available in the largely nonverbal right hemisphere. However, they are able to recreate the picture with their left hand, which is also controlled by the right hemisphere. When the more verbal left hemisphere sees the picture that the hand drew, the patient is able to name it (assuming the left hemisphere can interpret what was drawn by the left hand).

Illustrations (a) and (b) show the corpus callosum’s location in the brain in front and side views. Photograph (c) shows the corpus callosum in a dissected brain.

Figure BB.19 (a, b) The corpus callosum connects the left and right hemispheres of the brain. (c) A scientist spreads this dissected sheep brain apart to show the corpus callosum between the hemispheres. (credit c: modification of work by Aaron Bornstein)

Much of what we know about the functions of different areas of the brain comes from studying changes in the behaviour and ability of individuals who have suffered damage to the brain. For example, researchers study the behavioural changes caused by strokes to learn about the functions of specific brain areas. A stroke, caused by an interruption of blood flow to a region in the brain, causes a loss of brain function in the affected region. The damage can be in a small area, and, if it is, this gives researchers the opportunity to link any resulting behavioural changes to a specific area. The types of deficits displayed after a stroke will be largely dependent on where in the brain the damage occurred.

Consider Isa, who is 62 years old, and known to be intelligent and self-sufficient. Recently, Isa suffered a stroke in the front portion of their right hemisphere. As a result, Isa has great difficulty moving their left leg. (As you learned earlier, the right hemisphere controls the left side of the body; also, the brain’s main motor centres are located at the front of the head, in the frontal lobe.) Isa has also experienced behavioural changes. For example, while in the produce section of the grocery store, they sometimes eats grapes, strawberries, and apples directly from their bins before paying for them. This behaviour—which would have been very embarrassing to Isa before the stroke—is consistent with damage in another region in the frontal lobe—the prefrontal cortex, which is associated with judgment, reasoning, and impulse control.

 

TRICKY TOPIC: HEMISPHERIC LATERALIZATION

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Neuroplasticity

Bob Woodruff, a reporter for ABC, suffered a traumatic brain injury after a bomb exploded next to the vehicle he was in while covering a news story in Iraq. As a consequence of these injuries, Woodruff experienced many cognitive deficits including difficulties with memory and language. However, over time and with the aid of intensive amounts of cognitive and speech therapy, Woodruff has shown an incredible recovery of function (Fernandez, 2008, October 16).

One of the factors that made this recovery possible was neuroplasticity. Neuroplasticity refers to how the nervous system can change and adapt. Neuroplasticity can occur in a variety of ways including personal experiences, developmental processes, or, as in Woodruff’s case, in response to some sort of damage or injury that has occurred. Neuroplasticity can involve creation of new synapses, pruning of synapses that are no longer used, changes in glial cells, and even the birth of new neurones. Because of neuroplasticity, our brains are constantly changing and adapting, and while our nervous system is most plastic when we are very young, as Woodruff’s case suggests, it is still capable of remarkable changes later in life.

WHAT DO YOU THINK?

Brain Death and Life Support

What would you do if your spouse or loved one was declared brain dead but their body was being kept alive by medical equipment? How should these situations be navigated?

On February 25, 1990, a Florida woman named Terri Schiavo went into cardiac arrest, apparently triggered by a bulimic episode. She was eventually revived, but her brain had been deprived of oxygen for a long time. Brain scans indicated that there was no activity in her cerebral cortex, and she suffered from severe and permanent cerebral atrophy. Basically, Schiavo was in a vegetative state. Medical professionals determined that she would never again be able to move, talk, or respond in any way. To remain alive, she required a feeding tube, and there was no chance that her situation would ever improve.

On occasion, Schiavo’s eyes would move, and sometimes she would groan. Despite the doctors’ insistence to the contrary, her parents believed that these were signs that she was trying to communicate with them.

After 12 years, Schiavo’s husband argued that his wife would not have wanted to be kept alive with no feelings, sensations, or brain activity. Her parents, however, were very much against removing her feeding tube. Eventually, the case made its way to the courts, both in the state of Florida and at the federal level. By 2005, the courts found in favour of Schiavo’s husband, and the feeding tube was removed on March 18, 2005. Schiavo died 13 days later.

Why did Schiavo’s eyes sometimes move, and why did she groan? Although the parts of her brain that control thought, voluntary movement, and feeling were completely damaged, her brainstem was still intact. Her medulla and pons maintained her breathing and caused involuntary movements of her eyes and the occasional groans.

More cases like that of Terri Schiavo continue to occur and involve difficult decisions for families and medical professionals. These cases are incredibly complex and emotional. What do you think about this?

Brain Imaging

You have learned how brain injury can provide information about the functions of different parts of the brain. Increasingly, however, we are able to obtain that information using brain imaging techniques on individuals who have not suffered brain injury. In this section, we take a more in-depth look at some of the techniques that are available for imaging the brain, including techniques that rely on radiation, magnetic fields, or electrical activity within the brain.

Techniques Involving Radiation

computerized tomography (CT) scan involves taking a number of x-rays of a particular section of a person’s body or brain (Figure BB.20). The x-rays pass through tissues of different densities at different rates, allowing a computer to construct an overall image of the area of the body being scanned. A CT scan is often used to determine whether someone has a tumour or significant brain atrophy.

Image (a) shows a brain scan where the brain matter’s appearance is fairly uniform. Image (b) shows a section of the brain that looks different from the surrounding tissue and is labeled “tumor.”

Figure BB.20 CT scan can be used to show brain tumours. (a) The image on the left shows a healthy brain, whereas (b) the image on the right indicates a brain tumour in the left frontal lobe. (credit a: modification of work by “Aceofhearts1968″/Wikimedia Commons; credit b: modification of work by Roland Schmitt et al)

Positron emission tomography (PET) scans create pictures of the living, active brain (Figure BB.21). An individual receiving a PET scan drinks or is injected with a mildly radioactive substance, called a tracer. Once in the bloodstream, the amount of tracer in any given region of the brain can be monitored. As a brain area becomes more active, more blood flows to that area. A computer monitors the movement of the tracer and creates a rough map of active and inactive areas of the brain during a given behaviour. PET scans show little detail, are unable to pinpoint events precisely in time, and require that the brain be exposed to radiation; therefore, this technique has been replaced by the fMRI as an alternative diagnostic tool. However, combined with CT, PET technology is still being used in certain contexts. For example, CT/PET scans allow better imaging of the activity of neurotransmitter receptors and open new avenues in schizophrenia research. In this hybrid CT/PET technology, CT contributes clear images of brain structures, while PET shows the brain’s activity.

A brain scan shows different parts of the brain in different colors.

Figure BB.21 PET scan is helpful for showing activity in different parts of the brain. (credit: Health and Human Services Department, National Institutes of Health)

Techniques Involving Magnetic Fields

In magnetic resonance imaging (MRI), a person is placed inside a machine that generates a strong magnetic field. The magnetic field causes the hydrogen atoms in the body’s cells to move. When the magnetic field is turned off, the hydrogen atoms emit electromagnetic signals as they return to their original positions. Tissues of different densities give off different signals, which a computer interprets and displays on a monitor. Functional magnetic resonance imaging (fMRI) operates on the same principles, but it shows changes in brain activity over time by tracking blood flow and oxygen levels. The fMRI provides more detailed images of the brain’s structure, as well as better accuracy in time, than is possible in PET scans (Figure BB.22). With their high level of detail, MRI and fMRI are often used to compare the brains of healthy individuals to the brains of individuals diagnosed with psychological disorders. This comparison helps determine what structural and functional differences exist between these populations.

A brain scan shows brain tissue in gray with some small areas highlighted red.

Figure BB.22 An fMRI shows activity in the brain over time. This image represents a single frame from an fMRI. (credit: modification of work by Kim J, Matthews NL, Park S.)

LINK TO LEARNING

Visit this virtual lab about MRI and fMRI to learn more.

Techniques Involving Electrical Activity

In some situations, it is helpful to gain an understanding of the overall activity of a person’s brain, without needing information on the actual location of the activity. Electroencephalography (EEG) serves this purpose by providing a measure of a brain’s electrical activity. An array of electrodes is placed around a person’s head (Figure BB.23). The signals received by the electrodes result in a printout of the electrical activity of his or her brain, or brainwaves, showing both the frequency (number of waves per second) and amplitude (height) of the recorded brainwaves, with an accuracy within milliseconds. Such information is especially helpful to researchers studying sleep patterns among individuals with sleep disorders.

A photograph depicts a person looking at a computer screen and using the keyboard and mouse. The person wears a white cap covered in electrodes and wires.

Figure BB.23 Using caps with electrodes, modern EEG research can study the precise timing of overall brain activities. (credit: SMI Eye Tracking)

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The Brain and Spinal Cord by Edited by Leanne Stevens is licensed under a Creative Commons Attribution 4.0 International License, except where otherwise noted.

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